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J Neuropathol Exp Neurol (2019) 78(12):110011

The three enzymes depicted in Figure 2C MtdA, Fch, and Fhs constitute the central pathway for methyl transfer, which is required for the synthesis of purines and amino acids, and for the initiation of protein translation

Some patients notice improvements within a few weeks, while others experience gradual benefits over several months, depending on the condition being treated