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Dihexa was administered to the APP/PS1 mice intraperitoneally from 6 to 9 months of age and 0.9% saline was administered to the wild type group once per day over a three month time period

This may involve increased iron uptake mediated by transferrin receptor 1 (TfR1) or reduced iron export facilitated by ferroportin (Fpn)

The viral titer, expressed as 50% tissue culture infectious dose (TCID 50 ), was calculated using the ReedMuench method

CP attenuates the immune system by suppressing lymphocyte (T and B cell) growth, hence diminishing inflammation and the autoimmune mechanisms associated with rheumatic illnesses (Klein et al