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However, an intervention study clearly demonstrates the lack of influence of an increase in serum UA on the progression of established PD

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This axis forms a complete regulatory circuit: pulmonary inflammation activates the HPA axis via widely distributed lung CRH receptors [369], while brain injury-induced glucocorticoid secretion in turn supports lung development and regulates key processes such as type II epithelial cell differentiation and surfactant synthesis [370, 371]

Veltkamp DMJ, Porras CP, Gant CM, Groenestege WMT, Kok MB, Verhaar MC, et al