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* The frequency of side effects is based on clinical trial data and post-marketing surveillance

This explains why gabapentin is sometimes used in MCAS patients with: Neuropathic pain Burning or tingling sensations Refractory pruritus (uncomfortable skin sensation that causes an urge to scratch) Pain out of proportion to objective findings Sleep disturbance driven by discomfort Randomized controlled trials in other populations (including uremic pruritus and neuropathic itch) demonstrate significant reductions in itch severity, supporting its role in centrally mediated pruritus

"It's been a long road with many failures, and it shows the importance of basic research - you just keep putting one foot in front of the other, and then suddenly you have something." Brunger and Dickey have filed a joint provisional patent application with Stanford's Office of Technology Licensing and the MD Anderson Cancer Center's Office of Technology Commercialization

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