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Together, our findings link -KG to energy sensing through AMPK translation and propose that targeting -KGYBX1-dependent AMPK translation can sensitize human cancer cells to energy stress for treatment

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For the control group, normal saline, which was dissolved in 2% dimethylsulfoxide (DMSO), was administered to the animal model and the treatment group, which were further separated into three different groups, were given three different doses of poncirin (5, 15 and 30 mg/kg) to identify whether the poncirin could reduce the damage caused by CCl4 administration