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Its particles can be incorporated into dental materials, releasing Zn + (combats oral bacteria and reduces dentin demineralization), F (inhibits demineralization), and Ca 2+ (enhances remineralization) ions to prevent secondary caries ( 2+ /Ca 2+ ( In vitro salivary titration assembly revealed that BioUnion-incorporated GIC provides higher initial fluoride release and a more sustained release profile under simulated oral conditions ( 2.1.2 Eugenol Whereas BioUnios strategy relies on antibacterial action and remineralization, eugenol acts primarily through pathogen inhibition and pulp inflammation modulation to prevent secondary caries ( These systems retain Eugenols functionality while achieving slow, sustained drug release, and can be triggered to release in response to specific environmental stimuli, thereby avoiding the cytotoxicity associated with long-term high-concentration release, improving biosafety ( 2+ , which achieves pH-responsive release via a phenolic hydroxyl-Zn 2+ cage-like network where the released Eugenol generates reactive oxygen species (ROS) to disrupt biofilms ( + ) and Gram-negative(G - ) bacteria while avoiding detrimental effects on resin polymerization and strength ( 2.1.3 Tannic acid Nanotechnology not only overcomes the limitations of natural active substances but also endows them with new functionalities

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Medjkane, S., Perichon, M., Marsolier, J., Dairou, J

In Amino acid metabolism pathway, the MCE+LPS group significantly increased the levels of L-aspartic acid, L-glutamate, L-serine, -alanine, and 5-Hydroxy-L-tryptophan compared with the LPS group