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Tiptoe gait due to flexion contracture of the ankles is a common early abnormality in children

Sands BE, Sandborn WJ, Panaccione R, O'Brien CD, Zhang H, Johanns J, Adedokun OJ, et al

demonstrated that S-nitrosothiols are essential in NO biology and influence blood pressure (24), and it has also been reported that thiol supplementation with GSH selectively improves human endothelial dysfunction by improving NO bioavailability (29)