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Conversely, SIRT3 overexpression has the opposite effects, 105 suggesting that SIRT3 inhibits AKT-dependent mitochondrial metabolism and EMT, thereby promoting ferroptosis

These findings suggest HIF-1 and HIF-2 synergistically regulate GBM malignancy and can act as a target to reduce hypoxia through therapies like HBO therapy

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None of the Epitalon-treated patients reported side effects