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Wenqun Li, [email protected] This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These agents not only kill tumor cells directly but also remodel the TME by promoting M1-macrophage polarization, suppressing immunosuppressive mediators (PD-L1, IDO-1, TGF-), and fostering durable CD8 T-cell responses [118,119,120,121,122,123]

Finally, cognition also declines with advancing age, particularly those cognitive functions that involve novel problem solving and psychomotor processing speed, with its own related impact on the older individuals ability to function independently