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NNMT inhibitors refers small molecule chemical entities that inhibit the enzymatic activity of NNMT, and includes the compounds of Formula I and Formula IA as well as compounds in Tables 1-3

1) Pro-angiogenic signaling (VEGFR2 Akt eNOS) In cell and animal models, BPC-157 increases VEGFR2 expression/internalization and activates downstream Akt-eNOS signaling, supporting endothelial tube formation and blood-flow recovery after ischemia

GLP-1 receptor agonist inhibited proinflammatory monocyte chemoattractant protein-1 secretion from human atherosclerotic plaque samples and monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor- (TNF-), and interleukin (IL)-1 secretion from human macrophages after ex vivo treatment

TRF1 (Fig