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In contrast, synthetic, proliferative VSMCswhich dominate pathologies such as atherosclerosisundergo a metabolic shift toward glycolysis and possess reduced antioxidant defenses, rendering them highly vulnerable to cuproptosis [154, 155]

Front Pharmacol:1590 Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D (2013) Prolonged biologically active colonic tissue levels of curcumin achieved after oral administrationa clinical pilot study including assessment of patient acceptability