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Another possibility, not investigated, is that since klotho is also produced in the somatotrophs, perhaps to modulate auto/paracrine GH production, increased klotho in acromegaly could be a consequence of increased GH secretion

2013;8(5):e63773

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Hansen R.S., Ellis N.A., Gartler S.M

More recently, it was shown that NAC but not Trolox can reverse cell death induced by the combination of L-BSO and MI-2 or Eeyarestatin I (EERI), which are inhibitors of deubiquitinases (DUB) 32