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Daily or twice-weekly dosing is unnecessary methionine, inositol, and choline have half-lives that support weekly administration, and more frequent dosing increases homocysteine and trimethylaminuria risk without additional metabolic benefit

The accumulation of DSBs has been linked to Hereditary sensory and autonomic neuropathy type 1 [41, 66], with the observation that high dose L-serine supplementation lowers plasma DSB levels and alleviates neuronal symptoms in HSAN1 patients, whereas alanine increases DSB levels and worsens peripheral neuropathy [67]

This makes them great for devices needing lots of power