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doi: 10.1016/J.CROHNS.2012.07.010 207 SuraiPF

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Another was the discovery that tight junctional permeability is dynamic, altered by systemic inflammation and other factors such as enterotoxins and the volume of fluid absorption [23, 39], initially reported in the early 1980s in clinical studies of intestinal permeability in arthritis and celiac disease patients [37, 40]

In these works, HMC3 cells are typically exposed to pro-inflammatory stimuli (LPS, cytokines, A, pro-oxidants, lipids, pathogen-derived molecules, or conditioned media) and then treated with pharmacological agents, nanoparticles, natural compounds, or subjected to genetic manipulations to either exacerbate cellular responses or rescue the basal conditions