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This is accompanied by the upregulation of ER stress-related proteins, including PERK, IRE1, ATF4, CHOP, XBP-1 and ATF6

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

Epigenome-wide association studies for common human diseases

The liver is especially relevant because it produces and uses large amounts of SAM, manages homocysteine through both remethylation and transsulfuration, synthesizes glutathione and carries out methylation- dependent reactions