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Wu and Fuh, 2025

Key Points More than 100 genetic loci have been associated with ankylosing spondylitis (AS), but together they explain less than 30% of AS heritability Multiple genes involved in antigen processing and presentation are associated with AS Investigation into the cellular sources and regulation of IL-17 production is crucial to understanding the pathogenesis of AS Cells involved in type 3 immunity produce IL-17 and include innate lymphoid cells and T cells Given the efficacy of the anti-IL-17 monoclonal antibody secukinumab in the treatment of AS, other therapies targeting type 3 immunity could also be effective Abstract Over the past 5 years, advances in high-throughput techniques and studies involving large cohorts of patients have led to considerable advances in the identification of novel genetic associations and immune pathways involved in ankylosing spondylitis (AS)

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial

2013;8(6):e65957