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[DOI] [PubMed] [Google Scholar] 22.Carmeliet P., Jain R.K

The standard retatrutide dose schedule is: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Week 17 onward: 8-12 mg once weekly (maintenance) In the combination context, many researchers find that 8 mg is sufficient for their maintenance dose rather than pushing to 12 mg, because the cagrilintide provides enough additional appetite suppression and satiety to make the extra 4 mg of retatrutide unnecessary

doi: 10.1111/j.1750-3639.2007.00064.x

Patients have been "tanked up" with daily injections, followed by weekly and then periodic ones that may continue the rest of their lives