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Hepatic safety profiles of emerging systemic therapies Deucravacitinib has demonstrated a favorable hepatic safety profile across multiple clinical trials, with ALT and AST elevations being generally mild, transient, and often related to underlying liver conditions or concomitant medications (Lebwohl et al

Haider A, Herde AM, Krmer SD, Varisco J, Keller C, Frauenknecht K, et al

[96] demonstrated heterotypic chronic stress (HeCS) could induce visceral hypersensitivity and sensitize colon-specific dorsal root ganglion (DRG) neurons through improving expression of nerve growth factor (NGF) in colonic muscularis externa and mucosa/submucosa

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