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If there is a membrane barrier that separates the aqueous solutions of different pH such as the GIT and the plasma, then the theoretical ratio R of drug concentration on either side of the membrane can be given by equations derived by Shore et al : for weak acids , for weak bases , If one considers the pH range in the GIT from 1 to 8, that of the stomach from 1 to 3 and of the intestine (from duodenum to colon) 5 to 8, then certain generalisations regarding ionisation and absorption of drugs can be made, as predicted from the pH-partition hypothesis: For Weak Acids : 1

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