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This combined effect facilitates A plaque buildup, contributing to AD pathogenesis ( Tau hyperphosphorylation: Chronic systemic inflammation and oxidative stress induced by gut microbiome dysbiosis activate tau kinases such as glycogen synthase kinase-3 beta (GSK-3) and cyclin-dependent kinase 5 (CDK5)

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Candidate genes and susceptibility alleles for autism are identified using a combination of techniques, including genome-wide and targeted analyses of allele sharing in sib-pairs, using association studies and transmission disequilibrium testing (TDT) of functional or positional candidate genes and examination of novel and recurrent cytogenetic aberrations