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However, the NIMH leaders propose to move from the examination of symptoms to that of systems, social, behavioral, physiological, genetic and, on this basis, to stratify patients into categories organized on the integration of biological data and life experience

Even when homocysteine levels are normal, risks may arise from impaired methylation, folate bioavailability, and environmental exposures

Key questions include the onset and course of symptoms, associated symptoms (heartburn, cough, voice changes), triggers, and any weight loss or systemic complaints

Since this SSE is associated with a loss of sensitivity and accuracy, the above-mentioned sample preparation methods describe compromises between the minimization of these matrix effects by removing matrix components during sample clean-up, and the ability to detect a broad spectrum of analytes with reasonable sample preparation efforts and adequate sensitivity