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How the Met allele affects BDNF secretion The Met allele disrupts the interaction between proBDNF and sortilin, a protein that directs BDNF into regulated secretory vesicles

Dihexa, with its combined N-hexanoic-Tyr-Ile-(6) aminohexanoic amide structure, exhibited a significantly extended half-life of 335.5 9.5 min, confirming that both N- and C-terminal modifications are effective strategies for improving metabolic stability [2]

doi: 10.1016/j.scr.2019.101605 58 MaZLiLLivingstonMJZhangDMiQZhangMet al

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