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Additionally, when vitamin C is incubated with peripheral blood lymphocytes in vitro, it reduces the production of various inflammatory cytokines, such as TNF- and IFN-, induced by lipopolysaccharide, whilst increasing the production of the anti-inflammatory cytokine IL-10 (50)

They mediate inflammatory responses

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structureactivity relationships, lead optimization, and chronic in vivo efficacy

It is now well established that CFTR functions as a cyclic adenosine monophosphate (cAMP)-dependent Cl channel in the apical membrane of secretory epithelia