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Description

Using bulk RNA-seq and intersectional transcriptomic analysis of various b-catenin-mutated and wild-type HCC animal models, we successfully derived MBGS

We demonstrated that 7OH is a potent low-efficacy agonist at mMOR and hMOR in the efficacy range comparable to buprenorphine ( E max ~ 20% versus DAMGO), in a cell-based assay without signaling amplification (Nb33 BRET assay)