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While fatigue is not among the most common side effects reported in clinical trials, some patients experience tiredness during treatment with this dual GIP and GLP-1 receptor agonist

Similarly, TMAO increased the mRNA expression of the stress-induced heat shock proteins HSP60 and GRP78, a hallmark of endoplasmic reticulum stress induction, which was related to an increased risk of AS (Mohammadi et al., 2015)

Starting at lower dose ranges and titrating based on tolerability and response represents a conservative approach consistent with general peptide therapy principles

The amount of glucose infusion depends on various factors such as residual enzyme activity, age and the level of stress due to anxiety or fever