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Identification of genotype-selective antitumor agentsw using synthetic lethal chemical screening in engineered human tumor cells

a peak incidence of spina bifida was noted amongst men conceived between February and March 1945, i.e., the depths of the Dutch famine during World War II ( Because folate status is a major determinant of blood homocysteine concentrations, the possible contribution of elevated homocysteine to the pathogenesis of NTDs has been postulated

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Parhizkar E, Sadeghinia D, Hamishehkar H, Yaqoubi S, Nokhodchi A, Alipour S