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Loss of membrane integrity associated with necrosis leads to the release of DAMPs from various intracellular compartments

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In the presence of mitochondrial superoxide dismutase (SOD), O 2 is converted into H 2 O 2 , which then diffuses from mitochondria into the cytosol

This is in line with the antigen-specificity of the response promoted by peptide immunotherapy, and resulted in the suppression by the pCons-induced T regs of the proliferation of CD4 + CD25 - T effectors cells and reduced production of proinflammatory cytokines