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[20,38] Protandim induces NRF2 nuclear translocation and subsequent transcription of the prototypical NRF2-regulated gene heme oxygenase-1 (HO-1) in human endothelial cells in vitro , [51] as well as transcription of erythrocyte SOD and catalase in vivo [38]

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The synergy of HCFe and CDDP not only proved efficacious but also showcased a commendable safety profile, as evidenced in studies involving cisplatin-resistant ESCC xenografts

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