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Long-term use of inhaled corticosteroids, especially at high doses, may contribute to decreased bone mineral density, increasing the risk of osteoporosis and fractures

[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects

57 , 96 - 99 Alcohol acute/chronic intoxication, and withdrawal combined together, may be particular illustration 59 , 60 much like the antagonization of thiopental anesthetic effect

Commenters stated that the policy could reduce access to care, particularly for high-cost new technologies such as innovative cell and gene therapies, and in rural communities