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However, this research is in its infancy, there are still plenty of challenges that need to be resolved, including long-term biosafety and the potential drug resistance, etc

Additionally, selenium may act as an immunostimulant, activating immune cells and counteracting immune checkpoint-mediated immunosuppression within the tumor microenvironment ( Figure 2 )

doi: 10.3389/fcell.2016.00016 Received 29 November 2015 Accepted 22 February 2016 Published 23 March 2016 Volume 4 - 2016 Edited by Gaetano Santulli, Columbia University in the City of New York, USA Reviewed by Yves Combarnous, Centre National de la Recherche Scientifique, France

Furthermore, we have elaborated on animal research and human clinical research separately and have not made a comparison