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The hallmark event of pyroptosis involves the processing of IL-18 and IL-1, and the activation of the pore-forming protein gasdermin-D (GSDMD), which culminates in cell membrane rupture and the release of IL-18 and IL-1 (103)

The Mayo Clinic describes Parkinson's disease as "a progressive disorder that affects the nervous system and the parts of the body controlled by the nerves." Parkinson's symptoms start materializing gradually and can begin with a tremor, stiffness or slowing of movement

Shimizu et al., 1998)