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Extracellular L-cysteine is oxidized to L-cystine and transported through the system into astrocytes (Shih et al., 2006), which release GSH via the multidrug resistance protein 1 (MRP1) as the first step in supplying cysteine for GSH synthesis in neurons (Minich et al., 2006)

Cancer cells, known to have a higher copper dependency compared to normal cells, may be particularly susceptible to cuproptosis-inducing agents

The expression of the Bax, casepase-3, Bcl-2 and Ki-67 in tumor tissues were detected by immunohistochemistry