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Nature 408(6809):239247

This results in a complete lack of pigmentation in skin, hair, and eyes

Glutathione metabolism of the brainthe role of astrocytes

its availability for NAD + synthesis can be partially controlled by modulation of purine nucleotide phosphorylase (PNP), which plays a role in purine salvage pathways where purine bases are recycled into nucleotides 24 and in metabolism of the NAD + precursor nicotinamide riboside (NR) 25