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Here, after one-cell-stage injection in Tg( tg:nlsEGFP ) embryos (Trubiroha et al, 2018), thyroid development was monitored in vivo at 55, 72, and 144 hours post-fertilization (hpf) for putative developmental defect affecting either early thyroid development, proliferation, migration, or thyroid functional maturation, respectively

Generation of the first structure-based pharmacophore model containing a selective zinc binding group feature to identify potential glyoxalase-1 inhibitors

Several key factorsincluding the pharmacologic targets of the drugs, host metabolism, genetic variability, and drug-drug interactionscontribute to the overall toxicity profile of oral agents