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Together, the present study delineates the role of GSH-GSNO module in regulating subcellular Fe homeostasis by transcriptional activation of the Fe transporters AtNRAMP3 , AtNRAMP4 and A t PIC1 via S-nitrosylation of the bHLH TFs during Fe deficiency

In the induction of ROS-mediated apoptosis, ROS overload causes the free radical attack of the membrane phospholipid, which in turn leads to a mitochondrial membrane depolarization resulting in the loss of MMP

Besides, it has been mentioned that SIRT1 can increase the activity of CPT1A in vitro tubular renal cells through the STAT1/Twist1 pathway (Song et al

Signal transducer and activator of transcription 3 (STAT3) binds to DNA response elements in the promoters of ferroptosis-related genes (FTH1, SLC7A11, and GPX4) and regulates their expression