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Among the 38 hits from the screen, we selected the 15 with a stronger senolytic effect on etoposide-treated SK-MEL-103 cells and, taking advantage of inhibitors of apoptosis (emricasan) or ferroptosis (liproxstatin 1), assessed their mode of action (Fig

One of the distinctive features of IGF-1 LR3 is its reduced affinity for insulin-like growth factor binding proteins (IGFBPs), a family of proteins that regulate the distribution and accessibility of IGFs within circulation