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These studies have been limited to acute or short-term administration, used very high doses, and only determined the effects on endothelial-dependent relaxation rather than other variables related to vascular disease progression or risk

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These drugs may not be safe if you: Have heart disease Have experienced a stroke Have been diagnosed with very low or high blood pressure Have diabetes that is not controlled with diet or medication Have severe liver or kidney disease Take nitrates (medications to treat heart conditions) such as Nitrostat (nitroglycerin) or Imdur (isosorbide mononitrate) Use anticoagulants (medications that help thin the blood), including Coumadin (warfarin), Pradaxa (dabigatran), or Xarelto (rivaroxaban) Take medications for high blood pressure or prostate enlargement, including alpha blockers like Cardura (doxazosin) or Minipress (prazosin) Oral ED medications often dont cause any major side effects

J Biol Chem 273: 56785684, 1998