Knockout of HGMB1 promoted the expression of NRF2 and its downstream targets, including HO-1, NQO1, GCLC, and GCLM, prevented the production of ROS and LDH and upregulated the level of GPX4 in renal mesangial cells (Fig
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Reports indicate that LIAS is underexpressed in numerous tumors, encompassing breast cancer (BRCA), COAD, kidney renal papillary cell carcinoma (KIRP), prostate adenocarcinoma (PRAD), rectal adenocarcinoma (READ), thyroid carcinoma (THCA), endometrial carcinoma (UCEC), acute myeloid leukemia (LAML), ovarian cancer (OV), and testicular germ cell tumors (TGCT)
Owing to its ability to accommodate multiple substrates, the TCA cycle plays a central role in cellular metabolism
