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These vegetables include broccoli (especially the flowers), kale, turnip greens, rutabagas, cabbage, Brussels sprouts (highest in glutathione), bok choy, and cauliflower

Further, we discuss the involvement of microglia and astrocytes in lesion formation and organization, remyelination, synaptic induction and pruning through different signaling pathways

We describe the inflammatory CNS environment that initiates neurotoxicity by imposing ion imbalance, excitotoxicity and oxidative stress, and by direct neuro-immune interactions, which collectively lead to mitochondrial dysfunction and epigenetic dysregulation

Such Hmox1 upregulation leads to iron overload, elevated levels of lipid peroxidation and ferroptosis stress to exacerbate SCD disease condition