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KPV also acts through a receptor-independent mechanism: direct suppression of NF-B nuclear translocation, the master transcription factor for inflammatory gene expression

Decreased or diminished expression and/or function of Cxs has been observed in most tumor cell lines and in solid tissue tumors, including melanomas

2.7 Methods for determining the biochemical indicators A glucometer was used to evaluate fasting blood glucose (FBG) levels, and an enzyme-linked immunosorbent assay (ELISA) was used to measure fasting insulin (FINS) levels