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The Ca 2+ imbalance and the malfunctioning of mitochondria form a vicious cyclemake the brain organization of ATP production insufficient, the release of mPTP leads to fine cytosolic edema, and results in intracellular Ca 2+ overload of the nerve cells, which eventually causes nerve cell death

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doi: 10.1016/j.neubiorev.2017.09.029, 41 ImpeyD.de la SalleS.BaddeleyA.KnottV