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Another study found that hypoxanthine boosts cysteine uptake via EAAC1 (a cysteine transporter) in HEK293 and SH-SY5Y cells, increasing intracellular GSH synthesis and exhibiting neuroprotective effects against oxidative stress (e.g., HO treatment) (192)

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In this work, without using noble metal nanomaterials, we developed a novel tag-based strategy for selective and quantitative analyses of GSH in solutions through traditional MALDI-TOF MS (Scheme 1)