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Chitosan nanoparticles (CN NPs) are particularly efficient delivery vehicles for both peptides as well as for chemotherapeutic drugs that which are used in breast cancer treatment due to their good biocompatibility, susceptibility to enzymatic hydrolysis, and for their high molecular carrying capacity.11 The topo isomerase inhibitor doxorubicin (Adriamycin) is frequently used alone or in combination for the eradication of solid tumors, but a major limitation of this agent is that it also induces non-cancer cell death, thereby resulting in numerous side effects including cardiovascular toxicity

A structured search was conducted across multiple databases, including PubMed, Scopus, and Web of Science, using keywords such as"polyphenols,""mitochondrial regulation,"and"oxidative stress."Studies published between 2019 and 2024 were reviewed, and only those with relevant methodologies and outcomes were retained