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These micelles showed synergistic effects and excellent anti-tumor efficacy in vitro and in vivo, proving a potential DDS for clinical applications [113]

Deboever N, Bayley, EM, Eisenberg MA, Hofstetter WL, Mehran RJ, Rice DC, Rajaram R, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Bednarski BK, Morris VK, Antonoff MB

Evidence from animal studies demonstrates that copper loading in rat hepatocytes leads to a significant increase in the mRNA expression of pyroptosis-related genes (caspase-1, IL-18, IL-1, and NLRP3) and the protein expression of caspase-1[111]

4k), immunohistochemistry analyses of sections of veins with thrombi (such as Supplementary Fig