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All of them are homodimers integrated in membranes which have a transmembrane domain characterized by a thioredoxin fold

To determine the effects of stimulating TCA cycle activity, we treated hepatocytes with dichloroacetate (DCA), which stimulates substrate entry into the TCA cycle by inhibiting PDKs (Constantin-Teodosiu et al., 1999, Wu et al., 2018)

Nicholas SB, Correa-Rotter R, Desai NR, et al

84,85,161163 When MLCK1 is recruited to PAMR, it generally phosphorylates the myosin light chain (MLC), resulting in contraction of the cytoskeleton and occludin internalization