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We focus on what endocrinologists can do, including reducing demand for healthcare services through better preventative health, focusing on high-value care and improving sustainability of medical equipment and pharmaceuticals through adopting circular economy principles (including reduce, reuse and, as a last resort, recycle)

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In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

Hence, an overabundance of ROS gives rise to a disturbance in the physiological endothelial function, resulting in vasoplegia, an excessive procoagulant state induced by the inhibition of the ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin motifs 13) enzyme, and impairment of mitochondrial integrity, thereby disturbing the signaling cascades governing thrombosis and inflammation (Dolmatova et al., 2021)