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It can be fused to either the N -terminus or C -terminus of a protein

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5.1 Overview of ferroptosis Ferroptosis is an iron-dependent form of cell death driven by the accumulation of lipid peroxides ( Ferroptosis depends on iron-dependent lipid peroxidation, with its key signaling regulation falling into three broad categories: iron metabolism, glutathione metabolism, and lipid metabolism ( is an essential amino acid antiporter composed of two subunits, SLC7A11 and SLC3A2