At 4 weeks of age, prior to the development of seizures in these mice, there was an ~50% increase in extracellular L-glu in the hippocampus of these mutant mice, as determined by microdialysis, which correlated with increases in markers of cell death in neurons in both the hippocampus and cortex
Another strategy involves modifying the peptide itself
Infect Immun 63:45314534 Martn I, Rodrguez A, Ala A, Martnez-Blanco M, Lozano-Ojalvo D, Crdoba JJ (2022) Control of Listeria monocytogenes growth and virulence in a traditional soft cheese model system based on lactic acid bacteria and a whey protein hydrolysate with antimicrobial activity
50 5.2.1.1 Growing pharmaceutical and biopharmaceutical R&D activities 5.2.1.2 Increasing demand for therapeutic antibodies 5.2.1.3 Increasing demand for biosimilars 5.2.1.4 Rising food safety concerns 5.2.1.5 Increasing use of liquid chromatography-mass spectrometry in analytics and research 5.2.2.1 Lack of skilled professionals 5.2.3.1 Rise of CMOs and CROs in pharmaceutical industry 5.2.3.2 Growing demand for disposable pre-packed columns 5.2.3.3 Growing demand for chromatography in drug development and omics research 5.2.3.4 Growing use of chromatography in proteomics 5.2.4.1 Presence of alternative technologies to chromatography 5.3 PORTER'S FIVE FORCES ANALYSIS 5.3.1 THREAT OF SUBSTITUTES 5.3.2 BARGAINING POWER OF SUPPLIERS 5.3.3 BARGAINING POWER OF BUYERS 5.3.4 THREAT OF NEW ENTRANTS 5.3.5 INTENSITY OF COMPETITIVE RIVALRY 5.4 KEY STAKEHOLDERS & BUYING CRITERIA 5.4.1 KEY STAKEHOLDERS IN BUYING PROCESS 5.5 MACROECONOMIC INDICATORS 5.5.1 GDP TRENDS AND FORECAST FOR MAJOR ECONOMIES 6 INDUSTRY TRENDS Navigate supply chain disruptions and tech innovations shaping chromatography resin markets globally
