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doi: 10.1016/j.psj.2023.103051 233

Specifically, the downregulation of PGC1 leads to increased glucose uptake and lactate production in TC, while ATP generation and oxygen consumption are decreased [58]

With topical use, rash and blistering have been reported with 5% alpha-lipoic acid creams, including a case in an 86-year-old woman who applied a 5% alpha-lipoic acid cream to her lower leg and thigh for chronic venous insufficiency [32], and cases of severe facial skin irritation from skin-aging creams containing 5% alpha-lipoic acid [33][34]

A pioneering exploratory clinical study ( 3.3 Interventional and implantable light sources The miniaturisation and biocompatibility of light sources are prerequisites for achieving intra-cavity therapy