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Current clinical guidelines for hyperuricemia and gout emphasize a dual approach: (1) acute flare management using nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, or corticosteroids and (2) long-term urate-lowering therapy (ULT) with xanthine oxidase inhibitors (e.g., allopurinol and febuxostat) or uricosurics (e.g., probenecid) (Karantas et al., 2024

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2023) The unpaired electron of the vitamin E radical (T-O ) is extensively delocalized over the aromatic ring, which results in low reactivity of T-O